MRI Compatible Microdrive
The use of functional magnetic resonance imaging (fMRI) in conjunction with local electrical microstimulation (EM) is a powerful tool for investigating brain network connectivity. This method requires MRI compatible devices that can precisely position electrodes without causing significant imaging artifacts. Eunha Baeg and colleagues have created an MRI compatible microdrive that uses an integrated penetration grid to guide electrodes and uses a microdrilling technique to eliminate the need for large craniotomies. Once implanted, screw-type actuators can be used to easily insert, remove, or reposition electrodes.
The design is highly customizable, allowing for the use of several different probe types, including electrodes for stimulation and recording, as well as optogenetic fibers, or drug cannulae. The CAD files can also be scaled such that the design can be used for various animal models. Thus, the presented design provides a versatile, cost-effective approach for fabricating MRI compatible microdrives.